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British National Formulary HomeContents
 
: Joint Formulary Committee. British National
Formulary. 53 ed. London: British Medical Association
and Royal Pharmaceutical Society of Great Britain;
2007. 
 BNF  
 

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Home > British National Formulary > 10 Musculoskeletal
and joint diseases > 10.1 Drugs used in rheumatic
diseases and gout > 10.1.1 Non-steroidal
anti-inflammatory drugs


DICLOFENAC SODIUM
Additional information interactions (Diclofenac);
hepatic impairment; renal impairment; pregnancy.
Indications pain and inflammation in rheumatic disease
(including juvenile arthritis) and other
musculoskeletal disorders; acute gout; postoperative
pain

Cautions see notes above; breast-feeding (Appendix 5);
interactions: Appendix 1 (NSAIDs)

Contra-indications see notes above; porphyria (section
9.8.2)

Intravenous use Additional contra-indications include
concomitant NSAID or anticoagulant use (including
low-dose heparin), history of haemorrhagic diathesis,
history of confirmed or suspected cerebrovascular
bleeding, operations with high risk of haemorrhage,
history of asthma, moderate or severe renal
impairment, hypovolaemia, dehydration

Side-effects see notes above; suppositories may cause
rectal irritation; injection site reactions

Dose  
By mouth, 75–150 mg daily in 2–3 divided doses

By deep intramuscular injection into the gluteal
muscle, acute exacerbations of pain and postoperative
pain, 75 mg once daily (twice daily in severe cases)
for max. of 2 days

Ureteric colic, 75 mg then a further 75 mg after 30
minutes if necessary

By intravenous infusion (in hospital setting), 75 mg
repeated if necessary after 4–6 hours for max. 2 days

Prevention of postoperative pain, initially after
surgery 25–50 mg over 15–60 minutes then 5 mg/hour for
max. 2 days

By rectum in suppositories, 75–150 mg daily in divided
doses

Max. total daily dose by any route 150 mg

child 1–12 years, juvenile arthritis, by mouth or by
rectum, 1–3 mg/kg daily in divided doses (25 mg e/c
tablets, 12.5 mg and 25 mg suppositories only)

child 6–12 years, postoperative pain, by rectum, 1–2
mg/kg daily in divided doses (12.5 mg and 25 mg
suppositories only) for max. 4 days





	
	
		
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